Human eosinophils lack human leukocyte elastase
نویسندگان
چکیده
منابع مشابه
Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro.
Neutrophils, eosinophils, and their proinflammatory constituents are important mediators of airway disease, and high levels of neutrophil proteases and eosinophil cationic protein (ECP) are found in sputum from patients with cystic fibrosis (CF). To investigate whether neutrophil proteases or CF sputum causes eosinophil degranulation, purified eosinophils from atopic asthmatic subjects were inc...
متن کاملActivation of human eosinophils through leukocyte immunoglobulin-like receptor 7.
Eosinophils are implicated prominently in allergic diseases and the host response to parasitic infections. Eosinophils may be activated in vitro by diverse classes of agonists such as immunoglobulins, lipid mediators, and cytokines. The leukocyte Ig-like receptors (LIRs) comprise a family of inhibitory and activating cell-surface receptors. Inhibitory LIRs down-regulate cellular responses throu...
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Frankincense extracts and boswellic acids, biologically active pentacyclic triterpenes of frankincense, block leukotriene biosynthesis and exert potent anti-inflammatory effects. Screening for additional effects of boswellic acids on further proinflammatory pathways, we observed that acetyl-11-keto-beta-boswellic acid, an established direct, nonredox and noncompetitive 5-lipoxygenase inhibitor,...
متن کاملIs Porcine Pancreatic Elastase a Suitable Model for Human Leukocyte Elastase?
Human Leukocyte Elastase (HLE) has recently been implicated as a poor prognostic marker in certain breast cancers and as a key component involved in Chronic Obstructive Pulmonary Diseases. Because HLE is so expensive, Porcine Pancreatic Elastase (PPE) has been used to model elastase activity and inhibition. This paper elucidates the differences and similarities between HLE and PPE through enzym...
متن کاملHuman leukocyte elastase inhibitors: designed variants of human pancreatic secretory trypsin inhibitor (hPSTI).
Variants of human secretory trypsin inhibitor were constructed with the aim of producing inhibitors specific for human leukocyte elastase. Models of the hPSTI/HLE and hPSTI/chymotrypsin complexes were generated by computer aided protein design and used to plan better HLE inhibitors. This resulted in the production of the strongest and most specific inhibitors of HLE known.
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 1996
ISSN: 0925-4439
DOI: 10.1016/0925-4439(95)00121-2